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Senior Systems Engineer

At Blueprint Medicines, as our name indicates, we are creating a blueprint for the future of healthcare.  We are a leading company in the personalized medicine revolution by focusing on delivering new medicines that are targeted to the genetic driver of disease.  We do this by leveraging our one-of-kind drug discovery platform to discover, develop and work to bring highly-selective kinase inhibitors to patients globally.  This prolific scientific platform has enabled Blueprint Medicine to build a pipeline of novel therapies that span three distinct areas of medicine; genomically defined cancers, rare diseases and cancer immunotherapy.

As a member of the IT team at Blueprint Medicines, you will partner with the organization and be a key contributor in different IT projects. This is an opportunity to provide support and leadership on key strategic business initiatives at a time of high-growth. If you enjoy working in a fast-paced and rapidly growing environment, this could be the opportunity for you!


  • Participate in a cross functional team to plan and design requirements for IT, financial, regulatory, and commercial systems.
  • Manage cloud infrastructure for corporate websites and application servers to ensure high availability and optimal performance.
  • Design scalable cloud infrastructure for our data analyses and other informatics pipelines.
  • Perform regular security audits of IT systems.
  • Maintain production databases and application servers to support research and development efforts.
  • Manage regular maintenance and testing of remote disaster recovery infrastructure.
  • Participate in business continuity planning with a cross functional team.
  • Make recommendations to improve and optimize existing processes
  • Provide desktop support to our users as needed.
  • Act as a resource/mentor for colleagues and potentially lead initiatives with manageable risks and resource requirements


  • Minimum 5 to 10 years of hands on technical experience
  • Bachelor’s degree in a related field


  • Proficiency in managing VMWare servers
  • Proficiency in managing and designing AWS cloud infrastructure
  • Proficiency in managing Windows and Linux operating systems
  • Proficiency in batch scripting (unix shell/powershell/aws-cli)
  • Proficiency in maintaining Oracle, SQL Server, and MySQL server databases
  • Proficiency in managing network monitoring solutions such as Zabbix
  • Familiarity with maintaining JBoss, Tomcat, IIS, and Sharepoint servers
  • Familiarity with Cisco networking equipment (Firewall/Switches) configurations
  • Experience managing Splunk is a plus.
  • Experience programming in python and perl is a plus.

All applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.


Blueprint Medicines’ mission is to dramatically improve the lives of patients with genomically defined diseases. Our singular focus is to use our deep understanding of the genetic blueprint of cancer and other diseases driven by the abnormal activation of kinases to craft highly selective medicines aimed at eradicating these diseases.

We don’t think in small steps. We think in giant leaps.

We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.

We know that what each and every one of us does matters and that our success depends on our ability to work together. We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun.

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