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Quantitative Systems Pharmacologist, DMPK

At Blueprint Medicines, as our name indicates, we are creating a blueprint for the future of healthcare.  We are a leading company in the personalized medicine revolution by focusing on delivering new medicines that are targeted to the genetic driver of disease.  We do this by leveraging our one-of-kind drug discovery platform to discover, develop and work to bring highly-selective kinase inhibitors to patients globally.  This prolific scientific platform has enabled Blueprint Medicine to build a pipeline of novel therapies that span three distinct areas of medicine; genomically defined cancers, rare diseases and cancer immunotherapy.

Blueprint Medicines is seeking an exceptional Quantitative Systems Pharmacology/DMPK scientist. Reporting to the Director of DMPK, this individual will be responsible for independently implementing quantitative translational strategies at a project level and contributing to expanding QSP capabilities beyond traditional modeling and simulation. The candidate will have an exciting opportunity to join a fast paced biotechnology company with an expansive pipeline and will be uniquely positioned to participate and contribute to a multitude of projects from early discovery to late-stage clinical development.

Responsibilities:

  • Represent Modeling and Simulation function to preclinical and clinical projects
  • Develop and execute Quantitative Translational Pharmacology strategy for oncology and immuno-oncology. Collaborate with Clinical to ensure transfer of quantitative knowledge to support the design of early clinical studies
  • Apply cellular to disease scale modeling to elucidate the key interaction between different cells, tissues and organs in response to disease state and/or to therapeutic interventions 
  • Participate in the evaluation and development of pharmacometric strategies in collaboration with Clinical Pharmacology
  • Author relevant regulatory submission documents (IND, IB, NDA)

Qualifications:

  • Master’s or Bachelor’s degree with a minimum of 5+ years of applicable experience in a pharmaceutical or biotechnology industry role is required; or, PhD (or Postdoc) in chemical biology, chemistry, toxicology, or pharmacology, in addition to 1-3+ years of pharmaceutical or biotechnology industry role is required
  • Demonstrated expertise (via publication) in modeling and simulation, especially in the area of Quantitative Systems Pharmacology
  • Proficient in mechanistic modeling using Matlab, R, ADAPT, NONMEM, or any equivalent software packages
  • Proven track records of applying M&S to issue resolution in drug discovery and developmental challenges and aiding in model-based drug development
  • Team player who can seamlessly embed with project teams and operate efficiently in a matrixed environment
  • Industrial experience as a mechanistic modeler in support of either preclinical or clinical project teams preferred

All applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

WHO WE ARE:

Blueprint Medicines’ mission is to dramatically improve the lives of patients with genomically defined diseases. Our singular focus is to use our deep understanding of the genetic blueprint of cancer and other diseases driven by the abnormal activation of kinases to craft highly selective medicines aimed at eradicating these diseases.

We don’t think in small steps. We think in giant leaps.

We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.

We know that what each and every one of us does matters and that our success depends on our ability to work together. We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun. 

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