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Principal Scientist/Associate Director, Pharmacology

Blueprint Medicines is a top-tier, publicly-traded (BPMC) Biopharmaceutical Company focused on discovering, developing and commercializing highly-selective kinase inhibitors for genomically defined diseases.  Originally funded by Third Rock Ventures, the company has built a sophisticated genomics platform and a one-of-kind annotated compound collection which is delivering a pipeline of novel therapies.  In just three years, four programs have been established in genomically defined cancers and one program in the rare genetic disease space.

Job description:

Blueprint Medicines is seeking a versatile and enthusiastic pharmacology leader to join a team working to advance genomically targeted therapies into clinical development. This individual will draw upon a strong track record of in vivo pharmacology to support a robust pipeline of oncology and immunotherapy approaches. The ideal candidate is a proven project leader who can influence colleagues via his/her technical knowledge, innovative approaches and strategic thinking. Candidates must be collaborative and enjoy a fast-paced and hands-on research environment.


  • Provide strategic and scientific leadership as part of cross-functional research teams.
  • Design and interpret in vivo efficacy and PK/PD studies, explore novel therapeutic hypotheses, and investigate mechanism of action for candidate small molecules.
  • Direct work with external academic / industry collaborators and with contract research organizations.
  • Oversee a subset of animal care facility activities.
  • Present clearly and succinctly in a variety of internal and external settings.

Qualifications and core competencies:

  • Ph.D. degree in oncology, immunology, pharmacology or a related field with at least 7 years of experience in small molecule drug discovery and development.
  • Deep understanding of in vivo pharmacology and track record of driving research stage programs into the clinic.
  • Experience with animal models of cancer, immune response and/or anti-tumor immunity, including transplantable tumor and genetically-engineered models.
  • Strong scientific writing skills. Experience in preparing regulatory submissions (e.g. IND).
  • Excellent organizational and time-management skills including the ability to manage several projects simultaneously.
  • A strong record in mentoring and career development of others.

All applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.


Blueprint Medicines’ mission is to dramatically improve the lives of patients with genomically defined diseases. Our singular focus is to use our deep understanding of the genetic blueprint of cancer and other diseases driven by the abnormal activation of kinases to craft highly selective medicines aimed at eradicating these diseases.

We don’t think in small steps. We think in giant leaps.

We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.

We know that what each and every one of us does matters and that our success depends on our ability to work together. We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun.


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