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Sr. Director, Translational Medicine

At Blueprint Medicines, as our name indicates, we are creating a blueprint for the future of healthcare. We are a leading company in the personalized medicine revolution by focusing on delivering new medicines that are targeted to the genetic driver of disease.  We do this by leveraging our one-of-a-kind drug discovery platform to discover, develop and work to bring highly-selective kinase inhibitors to patients globally.  This prolific scientific platform has enabled Blueprint Medicines to build a pipeline of novel therapies that span three distinct areas of medicine; genomically-defined cancers, rare diseases and cancer immunotherapy. 

Blueprint Medicines is looking for a highly motivated, creative and collaborative translational medicine leader with deep scientific expertise, leadership experience and the passion for bringing benefit to patients using precision medicine. This is a great opportunity to join a high-growth company that is focused on identifying the right patient population for our innovative, experimental medicines with even greater precision. As a member of our translational medicine team, you will be a vital part of shaping our translational strategy and vision. The candidate is expected to have a cutting-edge understanding of latest technologies and trends in Oncology, as well as Immuno-Oncology, therapeutic development.


  • Develop and coordinate biomarker, patient selection and companion diagnostic strategies for projects across Blueprint’s growing oncology portfolio
  • Lead the development, outsourcing and validation of clinically relevant biomarker assays (e.g., pharmacodynamic, predictive, prognostic and safety biomarkers)
  • Lead the development and implementation of companion diagnostic strategies, including co-development with in vitro diagnostic partners
  • Support global regulatory strategy and contribute to the generation of investigator brochures, IND applications, clinical protocols and other regulatory documents as appropriate
  • Provide deep domain area expertise to discovery and development project teams and further enhance Blueprint’s scientific reputation through high impact publications and presentations
  • Function as a scientific and business thought-leader inside and outside of the company and a key link to external community


  • PhD in molecular oncology, molecular/cell biology or immunology with relevant post-doctoral training
  • 8+ years of pharmaceutical or biotechnology industry experience in Oncology/Cancer Immunotherapy with expertise in oncology biomarker and companion diagnostic development
  • Ability to drive and influence projects from discovery through early clinical development with a focus on the identification of biomarkers of response and/or resistance to therapy
  • In depth experience in the discovery, validation and clinical implementation of innovative biomarkers and companion diagnostics
  • Excellent leadership, organizational, written and presentation skills working in a matrixed team environment


  • Demonstrated application of expertise to discovery research through early clinical development in the area of oncology and/or immuno-oncology
  • Familiarity with engaging and managing external efforts with contract research organizations and academic collaborators
  • Familiarity with data management and visualization tools and collaborating with computational biology to analyze complex genomic data sets emerging from clinical trials
  • At home in a results-driven, highly accountable environment where you can make a clear impact
  • A team player and mentor, who listens effectively, invites response and discussion and promotes creative problem solving
  • Ability to embrace Blueprint’s core values: Patients First, Thoughtfulness, Trust, Optimism and Urgency

All applicants will receive consideration for employment without regard to race, color, religion, sex, age, national origin, disability or protected veteran status.


Blueprint Medicines’ mission is to dramatically improve the lives of patients with genomically defined diseases. Our singular focus is to use our deep understanding of the genetic blueprint of cancer and other diseases driven by the abnormal activation of kinases to craft highly selective medicines aimed at eradicating these diseases.

We don’t think in small steps. We think in giant leaps.

We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.

We know that what each and every one of us does matters and that our success depends on our ability to work together. We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun.

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