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Sr. Scientist/Principal Scientist, X-Ray Crystallography

At Blueprint Medicines, as our name indicates, we are creating a blueprint for the future of healthcare.  We are a leading company in the personalized medicine revolution by focusing on delivering new medicines that are targeted to the genetic driver of disease.  We do this by leveraging our one-of-a-kind drug discovery platform to discover, develop and work to bring highly-selective kinase inhibitors to patients globally.  This prolific scientific platform has enabled Blueprint Medicines to build a pipeline of novel therapies that span three distinct areas of medicine; genomically defined cancers, rare diseases and cancer immunotherapy.

Blueprint Medicines has built an integrated platform that combines genomics and medicinal chemistry expertise with a novel kinase inhibitor library. To aid in our mission of rapidly developing highly selective compounds to address clear genomic drivers of disease, we are seeking an experienced and motivated scientist with expertise in x-ray crystallography to join our Drug Discovery team.  In this role, the ideal candidate will coordinate crystallographic needs and apply structure-based drug design principles across multiple discovery projects.


  • Provide x-ray crystallographic and protein structure-function support, including structure-based drug design, to on-going drug discovery projects and new target discovery initiatives
  • Coordinate with external contract research organizations on delivering target:inhibitor crystal structures including joint troubleshooting of construct, expression and crystallization issues on challenging targets  
  • Maximize the impact of structural information and associated data in drug discovery programs
  • Develop a deep expertise around kinase structure, kinase structure-function and small molecule SAR across the Kinome
  • Implement structural tools or databases for utilization among medicinal chemists


  • A PhD and 5+ years of protein crystallography or modeling experience within a pharmaceutical or biotechnology setting
  • A track record of impact in drug design efforts as evidenced by inventorship on multiple patents
  • Demonstrated experience in utilizing structural information to derive structure-function or structure-mechanism hypotheses to drive new strategies
  • A thorough knowledge of pharmaceutical drug discovery, capable of not only contributing to structural biology and related research efforts, but more broadly to pharmaceutical drug discovery projects
  • Experience effectively managing external collaborations or internal collaborations across sites or across disciplines
  • Demonstrated experience functioning within multi-disciplinary project teams
  • Experience in kinase inhibitor drug discovery highly preferred but not required
  • Candidates with a computational or medicinal chemistry background and deep experience in applying structural information and biophysical data to drug discovery programs will also be considered


  • Strong interpersonal and communication skills
  • A demonstrated ability to scientifically influence and motivate others
  • A desire to participate in a highly creative and enthusiastic environment
  • A team player, who listens effectively and invites response and discussion
  • A collaborator who communicates in an open, clear, complete, timely and consistent manner

All applicants will receive consideration for employment without regard to race, color, religion, sex, age, national origin, disability or protected veteran status.


Blueprint Medicines’ mission is to dramatically improve the lives of patients with genomically defined diseases. Our singular focus is to use our deep understanding of the genetic blueprint of cancer and other diseases driven by the abnormal activation of kinases to craft highly selective medicines aimed at eradicating these diseases.

We don’t think in small steps. We think in giant leaps.

We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.

We know that what each and every one of us does matters and that our success depends on our ability to work together. We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun.

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